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Assessing the Toxicity of Fuels and Fuel Additives

  • Challenge: A national governmental agency wanted to design a testing plan to assess the safety of new fuels and fuel additives from a human health standpoint. It asked Cardno ChemRisk to help understand the range of health effects known to be associated with evaporative and combustive emissions from fuels and fuel additives.
  • Approach: Cardno ChemRisk reviewed the toxicity literature on: whole evaporative and combustive emissions from fuels (including diesel fuel); volatile organic compounds commonly found in these emissions; and metals used as fuel additives or found as impurities in crude oil. Based on the identified key health effects for these chemicals and mixtures, Cardno ChemRisk reviewed the available biological assays to assess the range of health effects.
  • Findings: The key health effects primarily included respiratory and cardiovascular toxicities, though other common health impacts were also identified. Based on the weight-of-evidence on the likely health effects associated with fuels and fuel additives, Cardno ChemRisk provided recommendations on the use of both validated and alternative assays to assess these effects, including an evaluation of the benefits and disadvantages of the available options.
  • Value: Cardno ChemRisk provided the tools and recommendations necessary for the government agency to develop and implement a tiered toxicity testing strategy for evaluation of new fuels and fuel additives.

Tags: Case Studies by Industry: Automotive ,Government
Sort Case Study by Practice Area: Toxicology and Ecotoxicology
Chemical or Material: Fuel Additives ,Fuels

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