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News at Cardno ChemRisk

Cardno ChemRisk publishes updated analysis on “no-effect” levels for chrysotile asbestos for mesothelioma and lung cancer

The abstract for one of our papers that was just published in the Critical Reviews in Toxicology journal, entitled “An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma.” This is an update to our 2008 review article that was also published in Critical Reviews in Toxicology.

Our general findings are as follows:  
  • Based on our review of 16 eligible groups of chrysotile-exposed workers, we determined a best-estimate NOAEL range for lung cancer of 89-168 fibers/cc-years and for pleural mesothelioma of 208-415 fibers/cc-years.
  • None of the studies of workers exposed to medium and short (grade 4 – 7) chrysotile reported an increased risk of either disease at any exposure level. This supports that medium and short fiber chrysotile, which was used in hundreds of products (e.g., automotive brakes, and clutches, gaskets, roofing products, joint compound, etc.) may have no carcinogenic potential.
  • Of the seven cases of peritoneal mesothelioma reported in all studies combined, none were observed in the analyses of medium and short chrysotile-exposed workers in the absence of crocidolite exposure.
If you would like to discuss the paper, or if you have any questions regarding its content, please contact This e-mail address is being protected from spambots. You need JavaScript enabled to view it  to contact Jennifer Pierce directly.
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