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Luda Kopelovich

Luda Kopelovich

Ms. Luda Kopelovich is a Senior Associate Health Scientist with Cardno ChemRisk. She is a graduate of the University of California, Davis where she earned a bachelor’s of science degree in Neurobiology, Physiology, and Behavior, and also a bachelor’s of art degree in Russian.  She received her MPH from University of California, Berkeley in 2015.  At Cardno ChemRisk (formerly ChemRisk, LLC), Ms. Kopelovich is regularly involved in litigation support, literature reviews, and exposure assessment. Her training includes risk assessment, dose reconstruction and evaluation, and environmental and occupational epidemiology. Additionally, she has been involved with assessing occupational, environmental, and consumer exposure to various chemicals, including asbestos, silica, diacetyl, benzene, toluene, and dibutyl phthalate.

Posted by on in Centers of Excellence
Posted on behalf of Kevin Towle

Silicone breast implants have been used for augmentation or reconstructive breast surgeries since the 1960s. However, as their popularity skyrocketed, concerns began to arise regarding a potential link between the implants and autoimmune or connective tissue diseases. Numerous studies were conducted on this issue in the 1980s and beyond, yielding mixed results. In 1992, the FDA issued a moratorium on silicone implants for safety assessment, and this ban remained in effect until 2006. Today, silicone implants are used in 84% of breast augmentation surgeries. According to the American Society of Plastic Surgeons, there were approximately 243,600 silicone breast augmentations in 2016.

During the FDA's moratorium, in 2000, a meta-analysis was conducted that examined 20 studies between 1984 and 1999. This analysis found no association between silicone breast implants and autoimmune disease. Since then, tools for autoimmune disease diagnosis have improved. Subsequent studies utilizing these tools found positive associations in previously unexamined cohorts, which demonstrated a need for an updated meta-analysis to quantitatively measure any association between silicone implants and autoimmune disease.

In 2016, Cardno ChemRisk conducted a meta-analysis of the results of 20 cohort and nine case control studies. Silicone breast implants were associated with a non-statistically significant decreased risk for all connective tissue diseases, meta-RR 0.87 (95% CI: 0.62-1.21). When stratified by disease, silicone breast implants were associated with a non-statistically significant increased risk of sclerosis, meta-RR 1.14 (0.75-1.74), and a non-statistically significant decreased risk of rheumatoid arthritis, meta-RR 0.75 (95% CI: 0.52-1.08), and systemic lupus erythematosus, meta-RR 0.90 (95% CI: 0.43-1.87). These findings suggest that silicone breast implant exposure is not associated with autoimmune disease among women.

If you would like to receive more information on this topic, please contact Dr. Andrew Monnot
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Posted by on in Centers of Excellence
Two of our scientists, Drs. Marisa Kreider and Denise Hill, will be presenting at a webinar titled "Risk Communication - It's Not Just About the Facts", hosted by the Society of Petroleum Engineers (SPE), on Tuesday, July 25th at 9:30AM (EDT). The presenters will be discussing various aspects of risk communication. Dr. Hill will be covering risk perception, specifically public concerns regarding land-based fracking operations, and Dr. Kreider's talk will be focused around the science of risk assessment and the challenges hazard-driven regulatory agendas are causing with respect to risk communication.  You can register for this webinar here

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We are excited to announce that one of our industrial hygienists, Mr. Thomas Slavin, received the best paper award at the 2017 American Foundry Society Metalcasting Congress, for the paper titled "Controlling Exposures to Air Contaminants in Metalcasting – a Performance-Based Approach". The paper, co-written with Mr. Robert Scholz, presents an approach to selecting controls for air contaminants in the metalcasting industry. It not only provides an evaluation of the current protocols used by the industry, but also provides foundries with additional guidelines to implement exposure control programs that are effective, reliable, and feasible. To learn more about the paper and about Cardno ChemRisk's capabilities, please contact Mr. Thomas Slavin.
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Posted by on in Centers of Excellence
Cardno ChemRisk recently presented an analysis examining the cancer risk associated with residential exposure to radioactive components in soils containing coal combustion residuals (CCRs) at the 2017 Society of Toxicology (SOT) annual conference. CCRs are waste products created as a result of burning coal at power plants during the production of electricity, and are one of the largest industrial waste streams generated in the United States. In 2012, approximately 40 percent of CCRs were beneficially used (i.e. concrete and wallboard), while the remaining 60 percent were disposed of in surface impoundments and landfills. Coal and CCRs are composed of various constituents, including naturally occurring radioactive materials. For our research, Cardno ChemRisk scientists utilized reported mean and upper bound isotope-specific radioactivity values to calculate the potential human health cancer risks associated with residential exposure to CCR-containing soil via ingestion of soil, inhalation of particulates emitted from soil, and external exposure to ionizing radiation. The mean cancer risk was 7 x 10-9, and the upper bound cancer risk was 1 x 10-8. Both the mean and upper bound calculated cancer risks were below the Environmental Protection Agency's (EPA) acceptable risk threshold of 1 x 10-6 to 1 x 10-4. These findings suggest that residents living on lots with ground soil containing CCRs are not at an increased risk of cancer due to the presence of naturally occurring radioactive components in CCRs under the exposure parameters analyzed.

If you would like to learn more about Cardno ChemRisk's experience with coal ash, please contact Paul Scott
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Posted by on in Centers of Excellence
Cardno ChemRisk scientists have published a white paper titled "community-focused risk assessment: a valuable tool for manufactured gas plant site remediation". The white paper explains the importance of assessing a community's potential risk from chemical exposures during the remediation of an MGP site. The approach develops airborne fenceline concentration objections (FCOs) for chemicals of concern that are health-protective of all members of a community. Air monitoring concentrations collected during remediation are then compared to the FCOs to ensure that there is no potential risk to community members throughout remediation. Communication distributed throughout this process can also mitigate the concerns of community members and avoid negative publicity and possible litigation. This method can be applied to many remediation scenarios and is tailored towards a community more so than comparison of monitored concentrations to regulatory standards.

Please contact Erin Hynds with any questions.
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Cardno ChemRisk is a respected scientific consulting firm headquartered in San Francisco with locations and consultants across the U.S. While our website provides a formal look at our capabilities, the Cardno ChemRisk View provides an informal voice too. Various Cardno ChemRisk consultants will be sharing news and views about current trends, happenings and methodologies in the industry. We’ll also highlight activities of interest at Cardno ChemRisk, within confidentiality restrictions of course.

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