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Centers of Excellence

Posted by on in Centers of Excellence

**Change of location for symposium. New location: Reed Smith Palo Alto, CA office

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Posted by on in Centers of Excellence
Recently, our study “An assessment of gender-specific risk of implant revision following primary total hip arthroplasty: a systematic review and meta-analysis” was published in the Journal of Arthroplasty (Towle and Monnot 2016). Scientists at Cardno ChemRisk synthesized and examined the evidence on the relative risk of revision in men and women following primary total hip arthroplasty (THA). THA surgeries involve the replacement of damaged hip joints with prosthetic components in an effort to mitigate hip pain. Over time, some THA surgeries require revision due to various modes of failure, such as dislocation, infection, or aseptic loosening. A better understanding of factors that influence the risk of revision due to hip implant failure would help reduce post-surgery complications. Therefore, we performed a meta-analysis to examine if males or females are at a higher risk of revision.

Overall, findings suggested that males are at an increased risk of revision following THA when compared to females. Additionally, this study provided evidence that gender-specific risk of revision may be impacted by geographic location (i.e. United States and Europe) and time period of THA operation (i.e. post-2000). The authors discussed potential risk factors for revision among male hip implant patients, including differences in hip anatomy, degree of surgical trauma during surgery, level of physical activity following surgery, as well as differences in primary care provider interactions.

The abstract of the article is available here.  If you have any questions regarding the paper, please contact Kevin Towle or Andrew Monnot.
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Posted by on in Centers of Excellence

Posted on behalf of author, Angela Perez.

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Posted by on in Centers of Excellence
Scientists at Cardno ChemRisk recently published a study titled “Anthophyllite asbestos: state of the science review” in the Journal of Applied Toxicology. The purpose of this research was to provide a comprehensive review of the toxicological, epidemiological and regulatory knowledge regarding anthophyllite and to understand how it compares to other types of asbestos. It also serves to give an overview of the available published literature on anthophyllite, including the occurrence of anthophyllite in talc and related health effects.

The authors reviewed publicly available documents on anthophyllite discussing its use, mining, properties, toxicity, exposure, and any potential health hazards. Based on their research, the authors found that:

·         Anthophyllite has been less researched than other asbestos types.

·         Anthophyllite can be found as a trace element or contaminant of other asbestos or talc deposits.

·         In studies from the 1970s and onward, it was reported that significant anthophyllite exposure in animal studies can cause asbestosis, lung cancer, and mesothelioma.

·         A study of Finnish Anthophyllite miners in the 1970s found exposure to anthophyllite caused asbestosis and lung cancer, but not mesothelioma, which was not linked with human exposure to anthophyllite until the mid-1990s.

·         Because of the lack of research on anthophyllite specifically, characterizing the health risks associated with exposure is difficult.

Overall, the authors concluded that anthophyllite may be more potent than other types of asbestos in causing asbestosis, but less potent in causing mesothelioma. However, further research is needed to fully understand the toxicity of pure anthophyllite.

The abstract of the article is available here. If you would like a full copy of the paper, or if you have any questions regarding its content, please contact Dr. Shannon Gaffney.
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Posted by on in Centers of Excellence
Posted on behalf of authors Michael Ierardi and Claire McMenamy.

TSCA Stakeholder Meeting for Risk Assessment and Risk Prioritization- Will Your Business be Ready?

The U.S. Environmental Protection Agency (EPA) held two public meetings to gather input that will inform a proposed rule to establish a risk-based process for chemical prioritization (August 10), in addition to its process for conducting risk evaluations to determine whether a chemical presents an unreasonable risk of injury to health or the environment under TSCA section 6(b) (August 9).

By June 2017, EPA must decide on a risk-based screening process for evaluating new and existing chemicals. The previous “unreasonable risk” standard will be replaced by the “safety standard” for regulating chemicals, which will consider both hazard and exposure in a risk-based approach that is protective of human health and the environment.

During these meetings, stakeholders from government, private industry, academia, non-governmental organizations, as well as medical professionals, offered feedback regarding their suggestions and concerns. Cardno ChemRisk scientists, Dr. Denise Hill and Ms. Claire McMenamy, attended the meetings, and offer the following observations, as well as the selected comments, repeatedly offered by multiple stakeholders:

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