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Centers of Excellence

Posted by on in Centers of Excellence
Pierce et al. published “An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma” in the online version of the Critical Reviews in Toxicology journal last month. This article is an update to the review article published in 2008 titled “An evaluation of reported no-effect chrysotile asbestos exposures for lung cancer and mesothelioma.”

The general findings of the updated study are:

·         Based on our review of 16 eligible groups of chrysotile-exposed workers, we determined a best-estimate NOAEL range for lung cancer of 89-168 fibers/cc-years and for pleural mesothelioma of 208-415 fibers/cc-years. 

·         None of the studies of workers exposed to medium and short (grade 4 – 7) chrysotile reported an increased risk of either disease at any exposure level.  This supports that medium and short fiber chrysotile, which was used in hundreds of products (e.g., automotive brakes, and clutches, gaskets, roofing products, joint compound, etc.) may have no carcinogenic potential.

·         Of the seven cases of peritoneal mesothelioma reported in all studies combined, none were observed in the analyses of medium and short chrysotile-exposed workers in the absence of crocidolite exposure.

The abstract of the article is available here.

Please contact Jennifer Pierce for more information.
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Posted by on in Centers of Excellence

Brooke Tvermoes, Ph.D., will be speaking at the GMA Science Forum – Connecting Sound Science with Sound Policy, to be held April 18-21, 2016, at the Capital Hilton in Washington, D.C. The GMA, or Grocery Manufacturers Association, is a trade association "representing the makers of the world's favorite food, beverage and consumer products" and assisting their members with diverse issues such as to "spur economic growth; ensure access to safe, healthy, and affordable foods; market [their] products responsibly; and tackle hunger relief." For the past decade, the GMA Science Forum has kept scientists and decision makers in the industry informed. This year's Forum will "provide attendees with multiple views and actions to be taken in order to ensure policies, laws and regulations are based on sound, up-to-date science, and achieve compliance with the ever changing regulatory environment."  

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Posted by on in Centers of Excellence
From March 13-16, 2016, many of our colleagues attended the SOT annual conference in New Orleans. A few of them are pictured, from left to right: Lauren Gloekler, Christina Trusty, Derek Dreschel, Marisa Kreider, Aaron Chapman, Matt Abramson. A full list of our presenters can be seen here. We received great feedback on our presentations and posters.

In particular, we are pleased to announce that Bethany Winans, Ph.D., received the Best Paper of the Year. Her paper, titled "Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses," was nominated by a researcher at Michigan State University and was selected from among four other nominated papers. The SOT cited its outstanding contribution to understanding the impact that early life exposure to pollutants has on the developing immune system.

Our staff fully enjoyed the conference, as well as the great ambiance of the city. We extend our congratulations to all of the presenters at the conference. We would like to thank the SOT organizers for hosting us. We would also like to thank everyone who took time to visit our posters and presentations. If you have any further questions, please see our presenter Q&A series, Parts I, II, III, IV and V, or reach out to the authors directly. Their contact information can be found in the professionals section of our website.  
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For our final featured presenter in our SOT spotlight series, Christina Trusty shares thoughts on her recent poster presentation below.

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Please read below for more information from Evan Beckett on his recent presentation, as we continue to spotlight our SOT 2016 presenters.

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