Latest blog entries All blog entries from Sun, 23 Apr 2017 07:52:26 +0000 en-gb Cardno ChemRisk Scientists Publish Paper on Lead in Wine

Posted on behalf of the authors, Lindsey Garnick and Kevin Towle

Cardno ChemRisk scientists recently published a human health risk assessment of lead (Pb) ingestion to adult wine drinkers.  Recently, it has been reported that wine samples contain detectable levels of heavy metals, including Pb. The presence of Pb in wine is believed to arise from soil composition, industrial emissions, fertilizers, and winery equipment. The goal of this study was to determine if Pb intake poses a health risk among adult consumers of wine. Cardno ChemRisk scientists performed a literature review of studies reporting Pb concentration in United States and international wines, determined adult wine consumption rates in the United States using NHANES dietary survey data, utilized the U.S. EPA’s Adult Lead Methodology (ALM) model to estimate adult blood lead levels (BLLs) from wine consumption under various exposure scenarios, and compared modeled BLLs to guidance values. According to our results, all modeled BLLs were below the Center for Disease Control (CDC) BLL guidance value of 5 μg/dL.

Overall, our findings suggest that Pb content in wine does not pose a health risk to adult wine consumers.

The full article can be found here.


If you have further questions, please reach out to Kevin Towle.


]]> (Melanie Nembhard) Centers of Excellence Fri, 21 Apr 2017 15:11:49 +0000
Ochratoxin A (OTA) in U.S. Breakfast Cereals Posted on behalf of the author, Christina Trusty

Cardno ChemRisk presented an abstract at the 2017 Society of Toxicology Annual Meeting in Baltimore, Maryland titled, “Risk Assessment for the Consumption of Ochratoxin A (OTA) in Breakfast Cereals in the US”.

Ochratoxin A (OTA) is a naturally occurring mycotoxin and is a stable contaminant found in the production and storage of cereals and grains. OTA is of interest, as it has been shown to cause kidney tumors in mice and rats, and is classified as a Group 2B carcinogen by the International Agency for Research on Cancer (IARC). Additionally, Health Canada has derived a negligible cancer risk intake (NCRI) of 4 ng/kg bw/day, corresponding to a 1 in 100,000 risk level, based on a TD05 of 19.6 μg/kg bw/day and a safety factor of 5000. In the U.S., there is currently no health based guidance value for OTA.

In our analysis, we assessed the potential cancer risks associated with consumption of OTA in different grain-based cereals in the U.S. OTA intake was estimated using the mean and maximum estimates of U.S. cereal consumption (various age groups, as reported in the EPA 2011 Exposure Factor Handbook) and mean OTA levels in grain-based U.S. cereals (as calculated from published literature).

Our results illustrated that OTA doses associated with mean cereal consumption rates are below the NCRI “negligible cancer risk” dose. The OTA doses associated with maximum consumption rates approach the NCRI value for several cereal types and exceed the NCRI for conventional oat cereal. Therefore, we concluded that the risk of cancer in the U.S. from OTA exposure is not likely to be of concern based on mean estimates of U.S. cereal consumption and mean OTA levels in grain-based cereals. However, under conditions of high consumption of oat cereal the OTA intake exceeds the NCRI.]]> (Melanie Nembhard) Centers of Excellence Fri, 14 Apr 2017 23:11:05 +0000
Cardno ChemRisk Celebrates Pi Day Cardno ChemRisk staff across the country celebrated Pi Day (March 14, 2017) while enjoying slices of pie and conversations about mathematics. Pi Day is an annual, worldwide celebration of the mathematical constant pi and is observed on March 14th since pi is approximately equal to 3.14 (out to three significant figures).  Pi is the ratio of a circle’s circumference to its diameter, and it is commonly represented in mathematics by the greek letter π.  Pi is the same value for all circles of any size, has been calculated to over one trillion digits beyond its decimal point, and will continue infinitely without repetition or pattern (as it is an irrational and transcendental number).  To learn more facts about pi or Pi Day, please visit:


BOU pi day 2017

Boulder, CO


DC pi day 2017

Washington, DC


PIT pi day 2017

Pittsburgh, PA


SF pi day 2017


San Francisco. CA



]]> (Anders Abelmann) Staff Activities Mon, 10 Apr 2017 16:58:19 +0000
Toxicity Testing under TSCA Reform

Posted on behalf of the authors, Michael Ierardi and Dr. Marisa Kreider.


With the promulgation of TSCA Reform, EPA has expanded authority to request toxicity testing and evaluation of new and existing chemicals in commerce to fill important data gaps and needs, resulting in increased burden on industry to sponsor and manage animal testing studies.  Such testing could be used to fill important data gaps regarding hazard for chemicals under evaluation or clarify assumptions made regarding hazard based on read-across from analogs.

We encourage companies to anticipate U.S. EPA’s testing requests for their inventory chemicals by:

·         Knowing what data is and is not available for specific chemicals, both publically (peer-reviewed literature, government documents, etc.) and privately (in-house);

·         Comparing chemical structures with the 56 Chemical Categories already identified by U.S. EPA and identifying key toxicity endpoints for the relevant categories;

·         Understanding potential analogs of chemicals of interest and their associated toxicities; and

·         Understanding potential use scenarios to predict relevant exposure pathways

By proactively complying with TSCA Reform toxicity testing requirements, companies can likely expect shorter turnaround times with U.S. EPA submissions, an advanced understanding of potential risks, and more control over their testing timescale. Otherwise, should companies choose to wait for a formal request from U.S. EPA, there could be delays with submission processes, limited time for execution of time-sensitive studies, and challenges with limited capacity at proficient laboratories. By working in tandem with our clients and taking their needs into consideration, Cardno ChemRisk can assist with selecting the proper route of toxicity testing for their specific chemicals that will satisfy regulatory requests.

We expect that toxicity testing requests under TSCA may include:

·         Mammalian toxicity testing;

·         Ecotoxicity testing (all trophic levels); and/or

·         Physical chemical properties predictive of toxicity

To learn more about how Cardno ChemRisk can assist with such request, please contact Dr. Marisa Kreider and Dr. Denise Hill.

]]> (Melanie Nembhard) Centers of Excellence Sat, 01 Apr 2017 00:01:23 +0000
Human Health Risk Assessment of NORM Exposure from Coal Ash Cardno ChemRisk recently presented an analysis examining the cancer risk associated with residential exposure to radioactive components in soils containing coal combustion residuals (CCRs) at the 2017 Society of Toxicology (SOT) annual conference. CCRs are waste products created as a result of burning coal at power plants during the production of electricity, and are one of the largest industrial waste streams generated in the United States. In 2012, approximately 40 percent of CCRs were beneficially used (i.e. concrete and wallboard), while the remaining 60 percent were disposed of in surface impoundments and landfills. Coal and CCRs are composed of various constituents, including naturally occurring radioactive materials. For our research, Cardno ChemRisk scientists utilized reported mean and upper bound isotope-specific radioactivity values to calculate the potential human health cancer risks associated with residential exposure to CCR-containing soil via ingestion of soil, inhalation of particulates emitted from soil, and external exposure to ionizing radiation. The mean cancer risk was 7 x 10-9, and the upper bound cancer risk was 1 x 10-8. Both the mean and upper bound calculated cancer risks were below the Environmental Protection Agency's (EPA) acceptable risk threshold of 1 x 10-6 to 1 x 10-4. These findings suggest that residents living on lots with ground soil containing CCRs are not at an increased risk of cancer due to the presence of naturally occurring radioactive components in CCRs under the exposure parameters analyzed.

If you would like to learn more about Cardno ChemRisk's experience with coal ash, please contact Paul Scott]]> (Luda Kopelovich) Centers of Excellence Thu, 06 Apr 2017 20:50:24 +0000