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Posted by on in Centers of Excellence
Posted on behalf of the author, Christina Trusty

Cardno ChemRisk presented an abstract at the 2017 Society of Toxicology Annual Meeting in Baltimore, Maryland titled, “Risk Assessment for the Consumption of Ochratoxin A (OTA) in Breakfast Cereals in the US”.

Ochratoxin A (OTA) is a naturally occurring mycotoxin and is a stable contaminant found in the production and storage of cereals and grains. OTA is of interest, as it has been shown to cause kidney tumors in mice and rats, and is classified as a Group 2B carcinogen by the International Agency for Research on Cancer (IARC). Additionally, Health Canada has derived a negligible cancer risk intake (NCRI) of 4 ng/kg bw/day, corresponding to a 1 in 100,000 risk level, based on a TD05 of 19.6 μg/kg bw/day and a safety factor of 5000. In the U.S., there is currently no health based guidance value for OTA.

In our analysis, we assessed the potential cancer risks associated with consumption of OTA in different grain-based cereals in the U.S. OTA intake was estimated using the mean and maximum estimates of U.S. cereal consumption (various age groups, as reported in the EPA 2011 Exposure Factor Handbook) and mean OTA levels in grain-based U.S. cereals (as calculated from published literature).

Our results illustrated that OTA doses associated with mean cereal consumption rates are below the NCRI “negligible cancer risk” dose. The OTA doses associated with maximum consumption rates approach the NCRI value for several cereal types and exceed the NCRI for conventional oat cereal. Therefore, we concluded that the risk of cancer in the U.S. from OTA exposure is not likely to be of concern based on mean estimates of U.S. cereal consumption and mean OTA levels in grain-based cereals. However, under conditions of high consumption of oat cereal the OTA intake exceeds the NCRI.
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Posted by on in Staff Activities

Cardno ChemRisk staff across the country celebrated Pi Day (March 14, 2017) while enjoying slices of pie and conversations about mathematics. Pi Day is an annual, worldwide celebration of the mathematical constant pi and is observed on March 14th since pi is approximately equal to 3.14 (out to three significant figures).  Pi is the ratio of a circle’s circumference to its diameter, and it is commonly represented in mathematics by the greek letter π.  Pi is the same value for all circles of any size, has been calculated to over one trillion digits beyond its decimal point, and will continue infinitely without repetition or pattern (as it is an irrational and transcendental number).  To learn more facts about pi or Pi Day, please visit: http://www.piday.org/.

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Posted by on in Centers of Excellence

Posted on behalf of the authors, Michael Ierardi and Dr. Marisa Kreider.

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Posted by on in Centers of Excellence
Cardno ChemRisk recently presented an analysis examining the cancer risk associated with residential exposure to radioactive components in soils containing coal combustion residuals (CCRs) at the 2017 Society of Toxicology (SOT) annual conference. CCRs are waste products created as a result of burning coal at power plants during the production of electricity, and are one of the largest industrial waste streams generated in the United States. In 2012, approximately 40 percent of CCRs were beneficially used (i.e. concrete and wallboard), while the remaining 60 percent were disposed of in surface impoundments and landfills. Coal and CCRs are composed of various constituents, including naturally occurring radioactive materials. For our research, Cardno ChemRisk scientists utilized reported mean and upper bound isotope-specific radioactivity values to calculate the potential human health cancer risks associated with residential exposure to CCR-containing soil via ingestion of soil, inhalation of particulates emitted from soil, and external exposure to ionizing radiation. The mean cancer risk was 7 x 10-9, and the upper bound cancer risk was 1 x 10-8. Both the mean and upper bound calculated cancer risks were below the Environmental Protection Agency's (EPA) acceptable risk threshold of 1 x 10-6 to 1 x 10-4. These findings suggest that residents living on lots with ground soil containing CCRs are not at an increased risk of cancer due to the presence of naturally occurring radioactive components in CCRs under the exposure parameters analyzed.

If you would like to learn more about Cardno ChemRisk's experience with coal ash, please contact Paul Scott
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Posted by on in Centers of Excellence
Cardno ChemRisk scientists have published a white paper titled "community-focused risk assessment: a valuable tool for manufactured gas plant site remediation". The white paper explains the importance of assessing a community's potential risk from chemical exposures during the remediation of an MGP site. The approach develops airborne fenceline concentration objections (FCOs) for chemicals of concern that are health-protective of all members of a community. Air monitoring concentrations collected during remediation are then compared to the FCOs to ensure that there is no potential risk to community members throughout remediation. Communication distributed throughout this process can also mitigate the concerns of community members and avoid negative publicity and possible litigation. This method can be applied to many remediation scenarios and is tailored towards a community more so than comparison of monitored concentrations to regulatory standards.

Please contact Erin Hynds with any questions.
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