Vinaora Nivo Slider

The Cardno ChemRisk View

  • Home
    Home This is where you can find all the blog posts throughout the site.
  • Categories
    Categories Displays a list of categories from this blog.
  • Tags
    Tags Displays a list of tags that have been used in the blog.
  • Bloggers
    Bloggers Search for your favorite blogger from this site.
  • Archives
    Archives Contains a list of blog posts that were created previously.
  • Login
    Login Login form
Subscribe to this list via RSS Blog posts tagged in styrene

Posted by on in Centers of Excellence
A recent report from the National Research Council (NRC) has upheld the listing of styrene as "reasonably anticipated to be a human carcinogen" in the National Toxicology Program's (NTP) 12th Report on Carcinogens (RoC). The NRC committee that conducted the review, both of the RoC and through an independent assessment, found that the listing is supported by "limited, but credible" evidence of carcinogenicity in human studies, "sufficient" evidence from animal studies, and "convincing relevant information" in mechanistic studies that demonstrated DNA damage in human cells exposed to styrene. Styrene is primarily a synthetic chemical used in the manufacture of products such as rubber, plastic, insulation, fiberglass, pipes, automobile parts, food containers, and carpet backing. Cigarette smoke and vehicle exhaust are sources of environmental exposure.

Referring to the NRC review, the American Chemistry Council noted that it was "important to point out that federal regulators have not changed their view that polystyrene is safe for foodservice packaging" and that the US Food and Drug Administration had "determined for more than 50 years that polystyrene is safe for use in foodservice products." The Styrene Information and Research Center (SIRC) issued a statement that consumers are not at risk from products made from styrene, citing the fact that NTP officials confirmed the safety of styrene-based products in the 2011 RoC.

The NRC committee noted that there was ambiguity regarding weighing the mechanistic evidence from data derived from in vitro studies, which considered alone could be made to support the listing of styrene as a known human carcinogen, according to the review. The committee stressed that further clarification and expanded guidance by NTP regarding the types and strength of mechanistic evidence and how it is used in the RoC listing criteria are needed in order to characterize the potential hazards posed by styrene. Implications of styrene's assessment regarding product formulation changes, permissible exposure limits, litigation potential, and other matters are yet to be determined.
Hits: 5480
Rate this blog entry:

The Cardno ChemRisk View

We're glad you decided to check us out.

Cardno ChemRisk is a respected scientific consulting firm headquartered in San Francisco with locations and consultants across the U.S. While our website provides a formal look at our capabilities, the Cardno ChemRisk View provides an informal voice too. Various Cardno ChemRisk consultants will be sharing news and views about current trends, happenings and methodologies in the industry. We’ll also highlight activities of interest at Cardno ChemRisk, within confidentiality restrictions of course.

The intent is to keep you informed and enable productive conversations, so please join in and get to know our staff and what makes our people unique. We are enthusiastic about the blogging experience and hope you will return often to learn and share. Stay tuned by subscribing to our blog or clicking on the RSS feed.