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Subscribe to this list via RSS Blog posts tagged in toxicology

Posted by on in Centers of Excellence

Cardno ChemRisk professionals will be offering a seminar series that will explore common and emerging issues encountered by EHS professionals in various industries. This seminar series will explore common and emerging issues encountered by EHS professionals in various industries. The purpose of these talks is to share our experience navigating a variety of challenges including: human health risk assessments of multi-constituent products, occupational exposure level derivation, product safety, regulatory compliance (e.g., TSCA, Prop. 65, OSHA, RoHS), baseline exposure assessments, occupational health considerations during emergencies, and emergency response.


First Webinar:

The first webinar for this series will be held on December 13, 2017 from 11:00-12:00 PM PST by Marisa Kreider, PhD, DABT:

  • Title: "Risk Assessment Under the “New TSCA”: How Manufacturers Can Help the EPA Accurately Characterize Their Industry" 
  • Summary: With the new legislation amending the Toxic Substances Control Act, chemicals in the United States are undergoing increased scrutiny with respect to potential impacts on human health and the environment. The U.S. Environmental Protection Agency is now required to make a definitive determination of risk for every chemical, including new chemicals and those already in commerce. This presentation will outline the methods that the U.S. EPA will use to evaluate chemical risk for both new and existing chemicals, and address how companies can assist the EPA in accurately representing their processes when determining risk associated with chemicals they use. 
  • ABIH® Diplomates can earn up to 1 technical contact hour for this event. 
  • CLICK HERE TO REGISTER


Future Webinars:

The next webinar for this series will be held on Wednesday January 24, 2018 at 11:00 AM PST/2:00 PM EST by Jim Keenan, PhD, MS, DABT

  • Title: "Developing Safety Procedures for Thermal Runaway Incidents”
  • Summary: Dr. Jim Keenan will discuss the inherent risks associated with lithium ion thermal runaway. His webinar will cover the danger of burns to workers as well as potential smoke inhalation.
  • ABIH® Diplomates can earn up to 1 technical contact hour for this event.
  • CLICK HERE TO REGISTER
Tagged in: ABIH EHS toxicology webinar
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Posted by on in Toxicology

This is the second post in a series highlighting Cardno ChemRisk staff presenting research at SOT in San Diego. You can find the previous post here.

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Posted by on in Toxicology


A group of researchers from Cardno ChemRisk will attend the 2015 Society of Toxicology's Annual Meeting in San Diego, California from March 22-26. At SOT, we will present recent research during posters and presentations.

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Posted by on in Centers of Excellence

Bisphenol A (BPA) is a monomer used to manufacture polycarbonate, a type of plastic used to make food containers and drinking bottles, as well as the resin lining in food cans and bottle tops. With an established reputation as a xenoestrogen (i.e., a “foreign” estrogen), BPA has been viewed as a reproductive and developmental toxicant by several scientific and public-interest organizations (e.g., the Environmental Working Group, Natural Resources Defense Council, and Plastic Pollution Coalition) because of research reporting sexual dimorphism, preneoplastic lesions in the prostate and mammary glands, altered prostate gland and urinary tract development, and early onset of puberty in laboratory animals at low doses (NTP, 2008, 2010). Because of studies such as these, coupled with the fact that BPA was detected in 93% of a sampled U.S. population, concern has been growing regarding the safety of this compound (Calafat et al., 2008).

Recent research indicates that previous studies showing that low dose BPA exposures caused reproductive and developmental effects in animals were, in fact, not low dose exposures comparable to those experienced by the human population. Teeguarden and Hanson-Drury, for example, found that “the ‘low-dose’ moniker describes exposures covering 8–12 orders of magnitude, the majority (91–99% of exposures) being greater than the upper bound of human exposure in the general infant, child and adult U.S. Population” (Teeguarden and Hanson-Drury, 2013, p. 935). New findings also demonstrate that BPA is metabolized and cleared from the human body considerably faster than in rodents, which were largely utilized for toxicity testing; this difference explains why effects are seen in test species, but also suggests that findings in animals bear little relevance for humans. In addition, blood levels resulting from typical human exposures have been determined to be too low to elicit any adverse effects (Teeguarden et al., 2013). In turn, the FDA maintains that “BPA is safe at the current levels occurring in foods,” and, although federal bans on BPA in baby bottles and infant formula packaging have recently been instituted, they were founded on the basis of “abandonment” (the prohibition of a chemical that has already been phased out of use by industry), rather than on evidence that dietary consumption of BPA may cause human health effects (U.S. FDA, 2013). Given the discrepancies between the scientifically established safety of BPA and its current public perception, it is important to conduct research of human relevance to ensure the safety of manufactured products and to avoid misinformation.

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The Cardno ChemRisk View

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Cardno ChemRisk is a respected scientific consulting firm headquartered in San Francisco with locations and consultants across the U.S. While our website provides a formal look at our capabilities, the Cardno ChemRisk View provides an informal voice too. Various Cardno ChemRisk consultants will be sharing news and views about current trends, happenings and methodologies in the industry. We’ll also highlight activities of interest at Cardno ChemRisk, within confidentiality restrictions of course.

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