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Posted by on in Centers of Excellence

Posted on behalf of the authors, Lindsey Garnick and Kevin Towle

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Posted by on in Centers of Excellence
Cardno ChemRisk scientists recently published History of Knowledge and Evolution of Occupational Health and Regulatory Aspects of Asbestos Exposure Science: 1900-1975" in the Critical Reviews in Toxicology journal.  The article provides a comprehensive review regarding the evolution of the foundation of occupational medicine and industrial hygiene knowledge with respect to asbestos and its risks from the early 1900s until the early-to-mid 1970s. In this review, we present the decisions, insights, challenges, and hallmark scientific discoveries that had the greatest impact on the historical actions of industrial hygienists in characterizing asbestos exposure and risk. 

If you have any questions or would like further information, please contact Dr. Christy Barlow at This e-mail address is being protected from spambots. You need JavaScript enabled to view it or (720) 305-5837.
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Posted by on in Centers of Excellence

Posted on behalf of author Lindsey Garnick

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Posted by on in Centers of Excellence
Scientists at Cardno ChemRisk recently published a study titled “Anthophyllite asbestos: state of the science review” in the Journal of Applied Toxicology. The purpose of this research was to provide a comprehensive review of the toxicological, epidemiological and regulatory knowledge regarding anthophyllite and to understand how it compares to other types of asbestos. It also serves to give an overview of the available published literature on anthophyllite, including the occurrence of anthophyllite in talc and related health effects.

The authors reviewed publicly available documents on anthophyllite discussing its use, mining, properties, toxicity, exposure, and any potential health hazards. Based on their research, the authors found that:

·         Anthophyllite has been less researched than other asbestos types.

·         Anthophyllite can be found as a trace element or contaminant of other asbestos or talc deposits.

·         In studies from the 1970s and onward, it was reported that significant anthophyllite exposure in animal studies can cause asbestosis, lung cancer, and mesothelioma.

·         A study of Finnish Anthophyllite miners in the 1970s found exposure to anthophyllite caused asbestosis and lung cancer, but not mesothelioma, which was not linked with human exposure to anthophyllite until the mid-1990s.

·         Because of the lack of research on anthophyllite specifically, characterizing the health risks associated with exposure is difficult.

Overall, the authors concluded that anthophyllite may be more potent than other types of asbestos in causing asbestosis, but less potent in causing mesothelioma. However, further research is needed to fully understand the toxicity of pure anthophyllite.

The abstract of the article is available here. If you would like a full copy of the paper, or if you have any questions regarding its content, please contact Dr. Shannon Gaffney.
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Posted by on in Centers of Excellence
Pierce et al. published “An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma” in the online version of the Critical Reviews in Toxicology journal last month. This article is an update to the review article published in 2008 titled “An evaluation of reported no-effect chrysotile asbestos exposures for lung cancer and mesothelioma.”

The general findings of the updated study are:

·         Based on our review of 16 eligible groups of chrysotile-exposed workers, we determined a best-estimate NOAEL range for lung cancer of 89-168 fibers/cc-years and for pleural mesothelioma of 208-415 fibers/cc-years. 

·         None of the studies of workers exposed to medium and short (grade 4 – 7) chrysotile reported an increased risk of either disease at any exposure level.  This supports that medium and short fiber chrysotile, which was used in hundreds of products (e.g., automotive brakes, and clutches, gaskets, roofing products, joint compound, etc.) may have no carcinogenic potential.

·         Of the seven cases of peritoneal mesothelioma reported in all studies combined, none were observed in the analyses of medium and short chrysotile-exposed workers in the absence of crocidolite exposure.

The abstract of the article is available here.

Please contact Jennifer Pierce for more information.
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