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Posted by on in Centers of Excellence
We are pleased to share with you an article our colleagues recently published in Inhalation Toxicology, titled “Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology.

In this paper, the authors pooled all of the mesothelioma studies of cosmetic talc miners and determined that, if in fact mesothelioma incidence had been significantly increased in these cohorts, it would have been detected using standard statistical techniques.  No increase at all was observed, and in fact there wasn’t a single reported case of mesothelioma in any cohort. 

The impetus for this study was a statement by EPA (in the early 1990’s) that the existing data were not sufficiently powerful to assess whether the miners were at risk.  Our analysis, which relies primarily on findings published since that time shows that there is now sufficient power to make such a determination.  As described in the paper, our findings are consistent with the fact that no pleural mesotheliomas have been observed in patients treated with very high doses of cosmetic talc placed directly in the pleura (“pluerodesis”).

Because miners were exposed to cosmetic talc at levels much higher than those associated with the use of cosmetic talc products, we conclude this is evidence that product use is highly unlikely to be a risk factor for mesothelioma.

If you have any questions or would like further information, please contact Dr. Stacey Benson.
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Posted by on in Centers of Excellence

Posted on behalf of the authors, Lindsey Garnick and Kevin Towle

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Posted by on in Centers of Excellence
Cardno ChemRisk scientists recently published History of Knowledge and Evolution of Occupational Health and Regulatory Aspects of Asbestos Exposure Science: 1900-1975" in the Critical Reviews in Toxicology journal.  The article provides a comprehensive review regarding the evolution of the foundation of occupational medicine and industrial hygiene knowledge with respect to asbestos and its risks from the early 1900s until the early-to-mid 1970s. In this review, we present the decisions, insights, challenges, and hallmark scientific discoveries that had the greatest impact on the historical actions of industrial hygienists in characterizing asbestos exposure and risk. 

If you have any questions or would like further information, please contact Dr. Christy Barlow at This e-mail address is being protected from spambots. You need JavaScript enabled to view it or (720) 305-5837.
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Posted by on in Centers of Excellence

Posted on behalf of author Lindsey Garnick

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Posted by on in Centers of Excellence
Scientists at Cardno ChemRisk recently published a study titled “Anthophyllite asbestos: state of the science review” in the Journal of Applied Toxicology. The purpose of this research was to provide a comprehensive review of the toxicological, epidemiological and regulatory knowledge regarding anthophyllite and to understand how it compares to other types of asbestos. It also serves to give an overview of the available published literature on anthophyllite, including the occurrence of anthophyllite in talc and related health effects.

The authors reviewed publicly available documents on anthophyllite discussing its use, mining, properties, toxicity, exposure, and any potential health hazards. Based on their research, the authors found that:

·         Anthophyllite has been less researched than other asbestos types.

·         Anthophyllite can be found as a trace element or contaminant of other asbestos or talc deposits.

·         In studies from the 1970s and onward, it was reported that significant anthophyllite exposure in animal studies can cause asbestosis, lung cancer, and mesothelioma.

·         A study of Finnish Anthophyllite miners in the 1970s found exposure to anthophyllite caused asbestosis and lung cancer, but not mesothelioma, which was not linked with human exposure to anthophyllite until the mid-1990s.

·         Because of the lack of research on anthophyllite specifically, characterizing the health risks associated with exposure is difficult.

Overall, the authors concluded that anthophyllite may be more potent than other types of asbestos in causing asbestosis, but less potent in causing mesothelioma. However, further research is needed to fully understand the toxicity of pure anthophyllite.

The abstract of the article is available here. If you would like a full copy of the paper, or if you have any questions regarding its content, please contact Dr. Shannon Gaffney.
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