Vinaora Nivo Slider

The Cardno ChemRisk View

  • Home
    Home This is where you can find all the blog posts throughout the site.
  • Categories
    Categories Displays a list of categories from this blog.
  • Tags
    Tags Displays a list of tags that have been used in the blog.
  • Bloggers
    Bloggers Search for your favorite blogger from this site.
  • Archives
    Archives Contains a list of blog posts that were created previously.
  • Login
    Login Login form
Subscribe to this list via RSS Blog posts tagged in risk assessment
Posted by on in Centers of Excellence
Cardno ChemRisk scientists have published a white paper titled "community-focused risk assessment: a valuable tool for manufactured gas plant site remediation". The white paper explains the importance of assessing a community's potential risk from chemical exposures during the remediation of an MGP site. The approach develops airborne fenceline concentration objections (FCOs) for chemicals of concern that are health-protective of all members of a community. Air monitoring concentrations collected during remediation are then compared to the FCOs to ensure that there is no potential risk to community members throughout remediation. Communication distributed throughout this process can also mitigate the concerns of community members and avoid negative publicity and possible litigation. This method can be applied to many remediation scenarios and is tailored towards a community more so than comparison of monitored concentrations to regulatory standards.

Please contact Erin Hynds with any questions.
Hits: 1452
Rate this blog entry:

Posted by on in Centers of Excellence
Posted on behalf of authors Michael Ierardi and Claire McMenamy.

TSCA Stakeholder Meeting for Risk Assessment and Risk Prioritization- Will Your Business be Ready?

The U.S. Environmental Protection Agency (EPA) held two public meetings to gather input that will inform a proposed rule to establish a risk-based process for chemical prioritization (August 10), in addition to its process for conducting risk evaluations to determine whether a chemical presents an unreasonable risk of injury to health or the environment under TSCA section 6(b) (August 9).

By June 2017, EPA must decide on a risk-based screening process for evaluating new and existing chemicals. The previous “unreasonable risk” standard will be replaced by the “safety standard” for regulating chemicals, which will consider both hazard and exposure in a risk-based approach that is protective of human health and the environment.

During these meetings, stakeholders from government, private industry, academia, non-governmental organizations, as well as medical professionals, offered feedback regarding their suggestions and concerns. Cardno ChemRisk scientists, Dr. Denise Hill and Ms. Claire McMenamy, attended the meetings, and offer the following observations, as well as the selected comments, repeatedly offered by multiple stakeholders:

Continue reading
Hits: 1727
Rate this blog entry:

Posted by on in Food/Beverage

There has been research showing the presence of lead (Pb) and cadmium (Cd) in chocolate since 2001, although no evidence of harm from its consumption has been reported. For example, As You Sow, a consumer health protection organization, recently performed laboratory testing to measure levels of Pb and Cd on 50 different chocolate products available at retailers across California. The organization reported that 35 of the 50 chocolate products contained measurable levels of Pb and/or Cd. However, one should note that the presence of these metals in a food product alone is not sufficient to evaluate potential risks to consumers. The scientists at Cardno-ChemRisk presented work entitled “An exposure and health risk assessment of lead (Pb) in chocolate” at the annual Society of Toxicology meeting in New Orleans last week. To assess whether the ingestion of Pb-containing chocolate could pose a health risk to adults and children, our scientists used the EPA’s Adult Lead Methodology (ALM) and Integrated Exposure Uptake Biokinetic (IEUBK) models to predict the blood Pb levels (BLLs) of adults and children (aged 1-7) ingesting various amount of chocolate on a daily basis for 1 year. The results of this analysis demonstrated that in all cases, background Pb exposure was the primary contributor to estimated BLLs in children and adults, and Pb exposure from chocolate did not significantly increase estimated BLLs. Our findings indicate that simply reporting the Pb content of a chocolate product is not sufficient to evaluate health risk; the health risks of Pb in chocolate should be evaluated in the context of estimated background exposures using predictive blood Pb models. The SOT abstract of “An exposure and health risk assessment of lead (Pb) in chocolate” can be found here, along with the other abstracts that our staff presented. For further information, please contact Matt Abramson.  

Continue reading
Hits: 3542
Rate this blog entry:

Posted by on in Centers of Excellence

On November 3, 2015, the California Department of Public Health (CDPH) instructed consumers to avoid eating Rock and Dungeness crab caught off the California coastline, because of "dangerous" levels of domoic acid found in the animals (CDPH, 2015). Domoic acid is a naturally occurring neurotoxin produced by algae that can bioaccumulate in shellfish, and can be harmful to humans who eat the contaminated food (WDFW, 2015). Symptoms of domoic acid poisoning in humans, which can occur within 30 minutes to 24 hours after eating the contaminated seafood, include nausea, abdominal cramps, vomiting, seizures, permanent memory loss, and possible death (CDPH, 2015). According to the data presented in EPA's AcTOR database, domoic acid is dose-responsive in humans, with no effect at 0.2-0.3 mg/kg, mild (gastrointestinal) symptoms at 0.9-1.9 mg/kg, and most serious symptoms at 1.9 – 4.2 mg/kg (EPA, 2015).

Algae blooms off the Pacific coast are not uncommon, but this year's bloom is unusually large and persistent, because of particularly warm ocean water temperatures (Sommer, 2015). According the CDPH, "the conditions that support the growth of this [algae] are impossible to predict, and it is unknown when the levels found in crab will subside" (CDPH, 2015). Currently, California's action level for domoic acid in crabs is 30 ppm in viscera and 20 ppm in meat (CDPH, 2015). Samples from at least 72 crabs were taken and the data indicates that a "significant percent of samples exceeded one or both of these criteria", with one rock crab sample as high as 190 ppm and numerous other samples exceeding 100 ppm (OEHHA, 2015). According to the Office of Environmental Health Hazard Assessment (OEHHA), "consumption of Dungeness and rock crabs is likely to pose a significant human health risk as a result of high levels of domoic acid" (OEHHA, 2015).

Based on a simple dose calculation, if a 160 lb person (73 kg) consumed a pound of crab meat during a meal (0.45 kg) that contained 190 ppm of domoic acid, their domoic acid dose would be approximately 1.2 mg/kg. Similarly, if a 120 lb person (54 kg) or 215 lb person (98 kg) consumed this same amount of crab, their domoic acid doses would be approximately 1.6 mg/kg and 0.87 mg/kg, respectively. As referenced above, these doses of domoic acid can cause gastrointestinal symptoms. These results are based on a simple dose calculation, using the 10th, 50th, and 90th percentile weights for males and females over 20 years of age, and do not account for sensitive populations or pharmacokinetics parameters, such as absorption and distribution (EPA, 2011).

There was a previous outbreak in 1987 that involved mussels with domoic acid concentrations ranging between 31 to 128 mg/100 g, or 310 to 1280 ppm (EPA, 2015). The ingested dose by symptomatic patients was estimated to be between 60 and 290 mg domoic acid per person, which correspond to 0.8 to 4 mg/kg doses, which can cause serious symptoms according to the dose response data described above. Three people died from eating contaminated shellfish, and hundreds of others reported symptoms (EPA, 2015). Currently, there is no antidote for domoic acid poisoning, but supportive and symptomatic treatment is available.

As of November 6, 2015, the California Department of Fish and Wildlife has delayed the opening day for commercial Dungeness crab fishing, which was scheduled to open November 15, and closed the commercial rock crab fishery, which is open year round (CDFW, 2015).

References :

CDFW (California Department of Fish and Wildlife). 2015. "Commercial Dungeness Crab Season Opener Delayed and Commerical Rock Crab Season Closed." November 6, 2015. Sacramento, CA: California Department of Fish and Wildlife. Retrieved from:

CDPH (California Dept. of Public Health). 2015. "CDPH issues warning about Dungeness and Rock crabs caught in waters along the Central and Northern California coast." November 3, 2015. Sacramento, CA: California Dept. of Public Health. Retrieved from:

EPA (Environmental Protection Agency). 2011. Exposure Factors Handbook, 2011 Edition. Washington, D.C.: National Center for Environmental Assessment, Office of Research and Development.

EPA (Environmental Protection Agency). 2015. Chemical summary: Domoic acid (14277-97-5). Retrieved on November 12, 2015, from EPA Aggregated Computational Toxicology Resource (ACToR) database, at:

OEHHA (Office of Environmental Health Hazard Assessment). 2015. "Memorandum: Domoic Acid Threat to Public Health". Novemner 3, 2015. Sacramenta, CA: California Office of Environmental Health Hazard Assessment. Retrieved from:

Sommer, L. 2015. "Why is an algae bloom closing crag season in California?" San Francisco, CA: KQED Science. November 5, 2015. Retrieved from:

Todd, E. C. 1993. "Domoic acid and amnesic shellfish poisoning-a review". Journal of Food Protection, 56(1), 69-83.

WDFW (Washington Dept. of Fish and Wildlife). 2015. "Domoic acid – A major concern to Washington State's shellfish lovers." Olympia, WA: Washington Dept. of Fish and Wildlife. Retrieved from:

Continue reading
Hits: 9211
Rate this blog entry:

Posted by on in Centers of Excellence
Posted on behalf of the author, Whitney Christian.
On August 1, Environment Canada and Health Canada proposed to use a cumulative risk assessment (CRA) approach to determine the combined risk to environmental and human health, posed by exposure to multiple phthalates (proposed CRA approach). A CRA approach for phthalates is already embraced by the World Health Organization, the International Program on Chemical Safety, and the U.S. Environmental Protection Agency. Ecological risk assessment would utilize a "sum of internal toxic units" approach, which is based on the presence of phthalates in living organisms and does not require dose-response toxicity data; likewise, human health risk assessment would utilize a hazard index approach that considers relative potency factors and assumes the effects of each phthalate are similar.
Canada's announcement about the CRA approach follows the identification of 14 phthalates as priorities for review under the federal Chemicals Management Plan. According to the Government of Canada, "some [phthalates] have been identified as potentially associated with reproductive and developmental effects; some have a wide range of consumer applications; some are associated with potential ecological effects of concern; and some have been identified as priorities internationally" (Phthalate Substance Grouping notice). Subsequently, Environment Canada and Health Canada added 14 more phthalates for prioritized review, bringing the total to 28 (workshop summary). These 28 phthalates include short-chain phthalate esters (DMP and DEP); medium-chain phthalate esters (DCHP, BCHP, DIBP, DBzP, CHIBP, B84P, BIOP, DMCHP, B79P, DIHepP, DPrP, DBP, BBP, DIOP, DEHP, DnHP and 79P); long-chain phthalate esters (DIDP, DUP, 610P, DnOP, D911P, D911P-2, DTDP, and DIUP); and DINP (long-chain phthalate ester for ecological review; medium-chain phthalate ester for human health review).
Hits: 5825
Rate this blog entry:

The Cardno ChemRisk View

We're glad you decided to check us out.

Cardno ChemRisk is a respected scientific consulting firm headquartered in San Francisco with locations and consultants across the U.S. While our website provides a formal look at our capabilities, the Cardno ChemRisk View provides an informal voice too. Various Cardno ChemRisk consultants will be sharing news and views about current trends, happenings and methodologies in the industry. We’ll also highlight activities of interest at Cardno ChemRisk, within confidentiality restrictions of course.

The intent is to keep you informed and enable productive conversations, so please join in and get to know our staff and what makes our people unique. We are enthusiastic about the blogging experience and hope you will return often to learn and share. Stay tuned by subscribing to our blog or clicking on the RSS feed.